WowAce

One of my profiles has limited mouse interaction with Player, Pet, Target, Pet Target, and Target of Target frames when in combat. While mouseover still seems to work, none of the frames respond to being clicked or highlight the player/pet/target upon mouseover. Once combat drops, the frames respond as normal.

I created this profile today for an alt, copying it from my main character's profile which has been working without issue. The only thing I changed was frame positioning. In fact, when I revert back to my main's profile, I don't experience the issue. However, I can't seem to find any setting I can adjust to fix this.